THE ACTIVITY OF ISO-NICOTINIC ACID HYDRAZIDE IN MURINE LEPROSY
نویسندگان
چکیده
منابع مشابه
comparison of catalytic activity of heteropoly compounds in the synthesis of bis(indolyl)alkanes.
heteropoly acids (hpa) and their salts have advantages as catalysts which make them both economically and environmentally attractive, strong br?nsted acidity, exhibiting fast reversible multi-electron redox transformations under rather mild conditions, very high solubility in polar solvents, fairly high thermal stability in the solid states, and efficient oxidizing ability, so that they are imp...
15 صفحه اولClinical Evaluation of Isonicotinic Acid Hydrazide as an Adjuvant in the Treatment of Lepromatous Leprosy
A clinical evaluation study of diasone, diaminodiphenyl sulfone (DDS) and dihydrostreptomycin (DHSM) separately, conducted in four institutions including Westfort, has been reported by Doull (2). The present evaluation study of the effects of isonicotinic acid hydrazide (isoniazid, INH) and of streptohydrazid on lepromatous leprosy, continued over a period of two years from September 1953 to Se...
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The iso-nicotinic acid hydrazides are valuable agents against tuberculosis exerting a powerful bacteriostatic action on the tubercle bacillus,’ diffusing readily into the cerebro spinal fluid,2 concentrating (as demonstrated by tissue cultures) effectively within macrophages3 and absorbed after oral administration without gastro-intestinal irritation. Such a combination of desirable attributes ...
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15 صفحه اولSynthesis and biological activity of novel amino acid-(N'-benzoyl) hydrazide and amino acid-(N'-nicotinoyl) hydrazide derivatives.
The coupling reaction of benzoic acid and nicotinic acid hydrazides with N- protected L-amino acids including valine, leucine, phenylalanine, glutamic acid and tyrosine is reported. The target compounds, N-Boc-amino acid-(N;-benzoyl)- and N- Boc-amino acid-(N;-nicotinoyl) hydrazides 5a-5e and 6a-6e were prepared in very high yields and purity using N-[(dimethylamino)-1H-1,2,3-triazolo[4,5-b]pyr...
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ژورنال
عنوان ژورنال: Leprosy Review
سال: 1953
ISSN: 0305-7518
DOI: 10.5935/0305-7518.19530003